Invitrogen and Emiliem Sign Major Kinase Screening Agreement, Kinase Drug Discovery Program Will Utilize Invitrogen's

Invitrogen Corporation (Nasdaq:IVGN), a provider of essential life science technologies for disease research and drug discovery, today announced a partnership with Emiliem, Inc. to screen the company's multi-kinase inhibitors using Invitrogen's SelectScreen(TM) platform. Invitrogen will perform biochemical kinase screening, cellular pathway profiling and P450 screening of Emiliem's compounds targeting cancer. Financial details of the multi-year agreement were not disclosed.

"We are fortunate to have a partner with the highest technical and scientific standards in the industry and unmatched cellular screening assays," said Dale E. Johnson, Pharm.D., Ph.D., President and CEO of Emiliem. "We view Invitrogen as a key component of our research arm in our quest to bring innovative therapeutics to cancer patients."

Invitrogen's SelectScreen(TM) profiling and screening service integrates industry-leading enzyme collections and cell-lines with state-of-the-art bioassay technologies to accelerate drug discovery programs. The first phase of the agreement will use the SelectScreen(TM) kinase profiling system to confirm specificity and potency of compounds in the Emiliem pipeline created through its K-STAR technology - a proprietary drug design platform for creating compounds that inhibit multiple kinases and other cellular targets known to be important in cancer progression. The second phase will use Invitrogen's SelectScreen(TM) cell-based pathway profiling service to interrogate the effects of Emiliem's compounds on biological pathways and the company's cytochrome P450 profiling service to determine the inhibitory profiles of lead molecules against drug metabolizing liver enzymes.

"Our services will provide critical information to Emiliem, including confirmation that Emiliem's compounds act on the kinases they are targeted to, determination of the compounds' effects on specific biological pathways and prediction of potential toxicity," noted Nick Ecos, Vice President and General Manager of Invitrogen's Discovery Sciences business. "Our selection for this research partnership demonstrates our strong credentials in kinase biology and small molecule screening."

About Emiliem

Emiliem, Inc. is a developmental-stage biotechnology company focused on the discovery and development of molecularly targeted oncology drugs. The company has developed proprietary drug design technologies that facilitate the inclusion of multiple kinase inhibitor profiles into single compounds. Emiliem's approach to developing targeted drugs includes the ability to identify proprietary biomarkers. Coupling drug discovery with biomarker identification and implementation increases the likelihood of achieving clinical trial endpoints and receiving approval to market these innovative drug candidates. The company is headquartered in Emeryville, California. For more information, visit www.emiliem.com

About Invitrogen

Invitrogen Corporation (Nasdaq:IVGN) provides products and services that support academic and government research institutions and pharmaceutical and biotech companies worldwide in their efforts to improve the human condition. The company provides essential life science technologies for disease research, drug discovery, and commercial bioproduction. Invitrogen's own research and development efforts are focused on breakthrough innovation in all major areas of biological discovery including functional genomics, proteomics, bioinformatics and cell biology -- placing Invitrogen's products in nearly every major laboratory in the world. Founded in 1987, Invitrogen is headquartered in Carlsbad, California, and conducts business in more than 70 countries around the world. The company is celebrating 20 years of accelerating scientific discovery. Invitrogen globally employs approximately 5,000 scientists and other professionals and had revenues of more than $1.26 billion in 2006. For more information, visit www.invitrogen.com

Per Peterson, M.D., Ph.D., Joins Board of Directors of Invitrogen Corporation

Invitrogen Corporation (Nasdaq:IVGN) today announced that Per Peterson, M.D., Ph.D. has been appointed to its board of directors, effective March 1, 2007. Dr. Peterson recently retired as Chairman, Research & Development, at Johnson & Johnson. As Chairman, he had responsibility for the Corporate Office of Science and Technology, the Enterprise-wide R&D Council, and Johnson & Johnson's cell therapy research activities. Dr. Peterson was also a member of the Executive Committee of Johnson & Johnson.

"We are very pleased to be adding someone of Dr. Peterson's reputation and experience to our board," said Greg Lucier, Invitrogen's Chairman and Chief Executive Officer. "As a leader in the life sciences, we are focused on creating technologies that accelerate biological understanding. In his role as director, Dr. Peterson will provide invaluable insight, advice and guidance to ensure Invitrogen remains on the cutting edge of innovation that makes a difference to researchers."

Dr. Peterson joined Johnson & Johnson in 1994 as Vice President, Drug Discovery, of the R.W. Johnson Pharmaceutical Research Institute. He was named Group Vice President of the Pharmaceutical Research Institute in April 1998 and its President in November 1998. In 2000, Dr. Peterson was named Chairman, Research & Development, Pharmaceuticals Group. Dr. Peterson became a Member of the Executive Committee in 2001.

Prior to joining Johnson & Johnson, Dr. Peterson spent eight years at Scripps Research Institute in La Jolla, CA, where he headed the Division of Molecular Immunogenetics before being appointed Chairman of the Department of Immunology in 1987. He had earlier served as Director of the Wallenberg Laboratory, as well as professor of cell biology at the University of Uppsala, Sweden.

Born in Kalmar, Sweden, Dr. Peterson received his B.M. in Medicine and his Ph.D. in Medicinal Biochemistry from the University of Uppsala, Sweden.

About Invitrogen

Invitrogen Corporation (Nasdaq:IVGN) provides products and services that support academic and government research institutions and pharmaceutical and biotech companies worldwide in their efforts to improve the human condition. The company provides essential life science technologies for disease research, drug discovery, and commercial bioproduction. Invitrogen's own research and development efforts are focused on breakthrough innovation in all major areas of biological discovery including functional genomics, proteomics, bioinformatics and cell biology -- placing Invitrogen's products in nearly every major laboratory in the world. Founded in 1987, Invitrogen is headquartered in Carlsbad, California, and conducts business in more than 70 countries around the world. The company is celebrating 20 years of accelerating scientific discovery. Invitrogen globally employs approximately 5,000 scientists and other professionals and had revenues of more than $1.26 billion in 2006. For more information, visit www.invitrogen.com

Sartorius AG Combines its Biotechnology Division with Stedim Biosystems

Sartorius AG, a worldwide leading laboratory and process equipment provider, signed a binding agreement today with the biopharmaceutical supplier Stedim Biosystems S.A., a company listed on the Paris stock exchange, and its major shareholders. Under the terms of this agreement, Sartorius acquires a substantial stake in Stedim and combines its Biotechnology Division with Stedim's business. Sartorius will pay 43 euros per share. Upon completion of this transaction, Sartorius will become Stedim's majority owner controlling the combined company.

Through the combination of the Sartorius and Stedim biotech businesses, Sartorius is substantially strengthening its position as a technology provider to the fast growing biopharmaceutical market. Stedim's board supports this deal. The overall transaction, which is subject to approval by Stedim's shareholders and to regulatory clearance, is expected to be completed in summer 2007. The combined company will be named "Sartorius Stedim Biotech S.A."

French-based Stedim is the pioneer for disposable bag systems for biopharmaceutical applications. Besides being a market leader in this segment, Stedim also has a product segment consisting of door systems for aseptic transfer technology and a unique proprietary freeze-thaw technology. Both of these technologies offer significant growth potential in the biopharmaceutical industry. In 2006, the company earned 91.4 million euros in sales, 44 percent of which were generated in North-America. Stedim employs some 540 persons at its locations in France, the U.S. and Tunisia.

Dr. Joachim Kreuzburg, CEO and Chairman of the Executive Board of Sartorius, commented: "This transaction significantly accelerates our strategy to offer customers fully integrated solutions for next generation biopharmaceutical manufacturing. It brings together two passionately innovative technology leaders who both have a strong customer base and who share a common vision. Our two companies' product array, technology platforms and regional strengths are highly complementary; therefore, we are a perfect match. Through this transaction, Sartorius is taking the next logical step in our company's development for the benefit of our customers, employees and shareholders. Given the strong double-digit growth rates in the biopharmaceutical markets and the shift in our markets toward disposable solutions, this is the ideal time for our Biotech Division and Stedim to come together."

Bernard Lemaitre, Chairman of Stedim, stated: "It is important to stress that each of the two companies brings a leading market position to this project. In this context, Stedim is a global leader in disposable bag systems and freeze-thaw technology. In establishing this alliance between two companies focused on the same customers and with complementary product portfolios, our first objective will be to implement a strategic and an industrial project with an impact much greater than the sum of the two parts. Once combined, Sartorius Biotechnology and Stedim have the realistic ambition of forming a worldwide market leader for single-use based technologies over the next five years. No other Group can offer the biopharmaceutical market such a broad range of solutions."

Transaction Details

The main steps of the transaction are as follows:

-- Sartorius acquires a substantial stake in Stedim from its founders, who will retain a significant shareholding.

-- Sartorius contributes its Biotechnology Division into Stedim (following the carve-out of this division, which is currently in progress).

-- As a result of this acquisition and contribution, Sartorius becomes the majority shareholder of Stedim Biosystems S.A. and will thus file a tender offer for its entire capital.

-- An extraordinary general meeting of Stedim's shareholders shall approve the contribution of Sartorius' Biotechnology Division into Stedim.

Sartorius invites Stedim shareholders to remain invested in Sartorius Stedim Biotech S.A. For each Stedim share, they shall have the option

-- of tendering for 43 euros in cash immediately, or

-- of keeping their shares and being granted a warrant as an incentive:

-- This warrant offers a cash payment after a maturity period of 24 months equal to the difference between the capitalized offer prize of 47.50 euros and the 30-day average trading price of the Sartorius Stedim Biotech shares over the reference period.

-- The guarantee shall not exceed payment of 20 euros per share.

Corporate Governance

The combined company will be headquartered at Stedim's main office in Aubagne, France. However, major global functions will be located at Sartorius headquarters in Goettingen, Germany. The board of Sartorius Stedim Biotech will have seven members, four from Sartorius and three from Stedim. Dr. Joachim Kreuzburg, CEO and Executive Board Chairman of the Sartorius Group, will assume the position of CEO and Chairman of Sartorius Stedim Biotech. Bernard Lemaitre, founder and current Chairman of Stedim, and Professor Dr. Arnold Picot, Chairman of the Sartorius AG Supervisory Board, will also be among the board members.

Business outlook for Sartorius Stedim Biotech

On a pro forma basis, Sartorius Stedim Biotech is expected to generate 400-420 million euros in sales revenue and to achieve an operating EBITA margin of approx. 14 percent in 2007. The transaction and integration costs are estimated at approx. 5 -10 million euros for 2007. Compound annual growth rate (CAGR) for the period of 2007 to 2011 is projected at 14-15 percent, while the EBITA margin is anticipated to further rise in the period up to 2011.

Business outlook for the Sartorius Group

Based on this transaction, Sartorius has adjusted its forecast for 2007 and its five-year plan upward. For 2007, pro forma sales revenue for the Sartorius Group is expected to increase to 660 - 680 million euros; the operating EBITA margin is anticipated to rise to approx. 12 percent (excluding the above-mentioned transaction and integration costs). CAGR for the period of 2007 to 2011 is forecasted to be at 11-12 percent. For the period up to 2011, the EBITA margin is targeted to further increase.

Sartorius in brief

The Sartorius Group is an internationally leading laboratory and process technology provider covering the segments of biotechnology and mechatronics. Its biotechnology division focuses on filtration and separation products as well as fermenters and bioreactors. In mechatronics, the company manufactures equipment featuring weighing, measurement and automation technology for laboratory and industrial applications. According to preliminary figures, in 2006 the technology group earned sales revenue of 521.1 million euros. The Goettingen-based company founded in 1870 currently employs approximately 3,800 persons.

Stedim Biosystems in brief

Founded in 1978, Stedim is the pioneer and a leading supplier of aseptic bag technologies for biopharmaceutical applications. The company also holds leading market positions in controlled freeze-thaw technology for biopharmaceutical systems as well as for single-use solutions for rapid aseptic fluid transfer. In 2006, Stedim earned 91.4 million euros, 44% of which was generated in the North-America. Stedim employs some 540 persons at its locations in France, USA and Tunisia.

Ikaria and Investor Group to Acquire INO Therapeutics in $670 Million

Ikaria Holdings, a newly formed investment company, announced today the signing of a definitive agreement to combine Ikaria Inc., a biotechnology company, and INO Therapeutics, the world leader in gaseous drugs including inhaled nitric oxide for treatment of hypoxic respiratory failure in newborns. The transaction, valued at approximately $670 million, is being financed by a group of private equity and venture capital investors led by New Mountain Capital, ARCH Venture Partners and Venrock Associates. INO Therapeutics is being acquired from The Linde Group (Deutsche Borse: LIN), which will retain an equity position in the new entity. The combined company, which will be called Ikaria Holdings, will have a leadership position in therapeutic gases and critical care medicine, a high-growth, multi-billion-dollar market. Its corporate headquarters will be in Clinton, N.J., with operations in several other locations including a research and development facility in Seattle.

"The merger of Ikaria and INO Therapeutics creates a fully integrated critical care therapeutics company with more than 300 employees, exceptional growth opportunities and the capability to significantly improve critical care for newborns and other patients in thousands of hospitals around the world," said David Shaw, chairman and chief executive officer-designate of the combined Ikaria entity. "From the outset, we will have a great team, substantial revenues and profitability, a well-established market position, outstanding products and technology, a deep R&D pipeline, an extensive commercialization infrastructure and strong financial resources. Each party brings important and complementary strengths in critical care medicine to the transaction, benefiting our customers and their patients, our investors and employees." Shaw is the founder of IDEXX Laboratories, a director of Ikaria, a senior advisor to New Mountain Capital and Venrock Associates and general partner of Black Point Group.

"The technology portfolio of this combined company is remarkable," said Robert Nelsen, co-founder and director of Ikaria and co-founder and managing director of ARCH Venture Partners. "Ikaria brings groundbreaking technology and a therapeutic portfolio based on research on hibernation and metabolic control via hydrogen sulfide from the laboratory of Dr. Mark Roth at the Fred Hutchinson Cancer Research Center. INO Therapeutics, among other things, has a strong patent and product position in nitric oxide, a signaling molecule with far-reaching medical applications ranging from regulation of blood pressure to fighting infection. The discovery of nitric oxide properties led to a 1998 Nobel Prize in Medicine and is the basis of INO Therapeutics' original work on inhaled nitric oxide with Dr. Warren Zapol at the Massachusetts General Hospital."

"We believe that the combination of Ikaria and INO Therapeutics provides a novel and exciting alternative to the traditional biotech model of financing development via sequential private and public fundraisings. Additionally, we see a wide range of attractive opportunities for synergies and collaboration on both sides and look forward to building even greater critical care capabilities, both organically and via acquisitions," said Bryan Roberts, an Ikaria director and managing general partner of Venrock Associates.

Ikaria and INO Therapeutics will continue their broad range of research and development programs in critical care drugs and drug delivery devices, including:

-- Phase III studies of treatments for chronic lung disease in premature newborns and cardiac surgery in adults.
-- Phase I and II studies of myocardial infarction, organ transplantation, ischemic stroke and other disease indications.
-- Preclinical studies of treatment of ischemia/reperfusion injury, vascular disease, acute respiratory distress syndrome, circulatory shock, hepatic injury, acute lung injury and autoimmune diseases.

Certain research programs at Ikaria and the Roth laboratory are supported by the Defense Advanced Research Projects Agency of the U.S. Department of Defense (DARPA). Beyond its internal R&D programs, Ikaria has an active business development program to acquire pharmaceutical products and medical devices useful in critical care applications.

"This unique, highly customized transaction results in the formation of a new company that combines high free cash flows, a strong capital base and a great pipeline of synergistic and important new products," said Alok Singh, managing director of New Mountain Capital. "We look forward to working with management, our venture partners and with Linde to fully realize the exciting prospects that lie ahead." Singh will join the Ikaria board with two other New Mountain directors including Steve Klinsky, founder and CEO of New Mountain Capital. Other directors will include David Shaw, Robert Nelsen, Bryan Roberts and a representative of Linde.

Dennis Smith, president and chief executive officer of INO Therapeutics, said, "On behalf of the INO Therapeutics team, we are delighted to join with Ikaria to create this category-leading critical care company. The combination will extend our current capabilities into new therapeutic technologies and applications. We will continue to build on our groundbreaking treatment for persistent pulmonary hypertension (PPHN) and hypoxic respiratory failure in newborns, which impacts the lives of thousands of patients every year. We are also pursuing additional indications as well as new drugs and drug delivery devices for a range of medical conditions. Finally, we are pleased that our long relationship with Linde will continue, as both a shareholder and an international distribution partner for our products."

Existing Ikaria investors will continue to be investors in the combined Company and approximately $300 million of new equity capital will be contributed by the investor group, including over $200 million from New Mountain Capital. In addition to the other named investors, the investor group will also include Altitude Life Science Ventures, Washington Research Foundation and Alexandria Equities. Debt financing for the transaction will be provided by Credit Suisse acting as lead arranger. Goldman Sachs served as the financial advisor to Ikaria. Heller Ehrman LLP served as legal advisor to Ikaria; Fried, Frank, Harris, Shriver & Jacobson LLP served as legal advisor to New Mountain Capital; and O'Melveny & Myers LLP served as legal advisor to the other venture capital investors. Linde was advised by Morgan Stanley, and Freshfields Bruckhaus Deringer provided legal counsel. The transaction, which is subject to Hart-Scott-Rodino approval, is expected to close by April 2007.

About Ikaria

Ikaria is a Seattle-based biotechnology company focused on developing breakthrough products for critical care. At the forefront of a new research domain in metabolic depression, the company is rapidly pursuing the development of products that would change critical care medicine. The company's technology is based on early research focused on metabolic control performed by Mark Roth, PhD, investigator at the Fred Hutchinson Cancer Research Center. For more information on Ikaria, please visit http://www.ikaria.com

About INO Therapeutics

INO Therapeutics is a specialty pharmaceutical company with strengths in the development, marketing and sales of critical care drugs and drug/device combinations that improve the lives of patients and fulfill unmet medical needs. The company's core product is INOmax® (nitric oxide) for inhalation. INOmax® is approved in the United States, Europe, Canada and parts of Latin America, and is supported by the INOvent® delivery system, INOcal® calibration mixtures and 24/7 medical and technical service and support. INO Therapeutics is headquartered in Clinton, N.J., and the company maintains a state-of-the-art manufacturing facility in Port Allen, La. Its parent company is The Linde Group. The Linde Group stock is publicly traded in Europe. For more information on INO Therapeutics, please visit http://www.inotherapeutics.com

About The Linde Group

The Linde Group is a leading global industrial gas and engineering company that boasts a workforce of more than 53,000 employees in over 70 countries across the globe. Following the acquisition of BOC Group, the company's Gas and Engineering segment now generates annual sales of approximately euro 12 billion. The strategy of The Linde Group is aimed at generating earnings- based growth. Its primary focus is on the targeted expansion of its international business by developing innovative products and services. For more information on The Linde Group, please visit http://www.linde.com

About New Mountain Capital

New Mountain Capital is a New York-based private equity firm investing for long-term capital appreciation through direct investment in growth equity transactions, leveraged acquisitions and management buyouts. New Mountain seeks out the highest-quality growth leaders in carefully selected industry sectors, and then works intensively with management to build the value of those companies. For more information on New Mountain Capital, please visit http://www.newmountaincapital.com

About ARCH Venture Partners

ARCH Venture Partners is a premier provider of seed and early-stage venture capital for technology firms. Over the last 20 years, ARCH has co- founded or led the seed round for more than 115 new ventures. ARCH enjoys special recognition as a leader in the successful commercialization of technologies developed at academic research institutions and national laboratories. ARCH's "concept to commerce" approach gives the firm special expertise in co-founding and building technology firms -- from startup through financial liquidity. For more information on ARCH Venture Partners, please visit http://www.archventure.com

About Venrock Associates

Venrock Associates is a premier venture capital firm with offices in Menlo Park, Calif.; New York; Cambridge, Mass. and Israel. Originally established as the venture capital arm of the Rockefeller family, Venrock continues a seven-decade tradition of funding entrepreneurs and establishing successful, enduring companies. Having invested $1.8 billion in 400 companies resulting in over 120 IPOs over the past 38 years, Venrock's investment returns place it among the top tier venture capital firms that have achieved consistently superior performance. With a primary focus on information technology, healthcare, and energy, portfolio companies have included Intel, Apple Computer, StrataCom, Check Point Software, and DoubleClick; Sirna Therapeutics, IDEXX Laboratories, Centocor, Idec Pharmaceuticals, Sugen, Millennium Pharmaceuticals and Illumina. For more information on Venrock Associates, please visit http://www.venrock.com

About 5AM Ventures

Founded in 2002, 5AM Ventures makes seed and early-stage investments in next-generation life science companies. As successful former company leaders and established venture capitalists, the 5AM Team takes a hands-on approach to company building. The 5AM portfolio, built on advanced life science technologies, is diversified among innovative platforms, spinouts from established biotechnology and pharmaceutical companies, and companies developing near-term products. For more information on 5AM Ventures, please visit http://www.5amventures.com

About Black Point Group

Black Point Group is a private equity partnership with investments in both public and private growth companies. The firm has offices in New York City and Portland, Maine. For more information on Black Point Group, please visit http://www.blackpointgroup.com

About Fred Hutchinson Cancer Research Center

At Fred Hutchinson Cancer Research Center, interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer. For more information, please visit http://www.fhcrc.org